The game text names 27 weapons, counting the knife, grenades and rocket launchers. 26 of them are in the 3DS version. Jill's Samurai Edge is also named and described, but it came as DLC for the HD version and is not in the 3DS game.
Pale Rider, Drake, High Roller and Muramasa are the Legendary weapons. They only drop in Raid Mode; the award missions Legendary Weapon and Legendary Raider call them super rare weapons. The G18, PC356, PSG1, Hydra and Infinite Rocket Launcher are also award-mission rewards for the campaign.
Weapon list
| Icon | Weapon | Type | In the 3DS game | Description |
|---|---|---|---|---|
 | Hand Grenade | Grenade | Yes | A destructive hand-thrown explosive. Works well on clusters of enemies. |
 | B.O.W. Decoy | Grenade | Yes | A timer based explosive that attracts creatures by using high frequencies. |
 | Handgun M92F | Handgun | Yes | - |
 | Handgun Government | Handgun | Yes | - |
 | Handgun G18 | Handgun | Yes; campaign reward for the mission Secret Sign 30 | - |
 | Handgun PC356 | Handgun | Yes; campaign reward for the mission B.O.W. Hunter | - |
 | Samurai Edge | Handgun | Not in the 3DS version (Jill's Samurai Edge was DLC for the HD version) | - |
 | Magnum Python | Magnum | Yes | - |
 | Magnum L. Hawk | Magnum | Yes | - |
| Pale Rider | Magnum | Raid Mode only (Legendary weapon) | - |
 | Shotgun Windham | Shotgun | Yes | - |
 | Shotgun Hydra | Shotgun | Yes; campaign reward for the mission NORMAL Cleared | - |
 | Shotgun M3 | Shotgun | Yes | - |
| Drake | Shotgun | Raid Mode only (Legendary weapon) | - |
 | Machine Gun MP5 | Machine Gun | Yes | - |
 | Machine Gun P-90 | Machine Gun | Yes | - |
 | Machine Gun AUG | Machine Gun | Yes | - |
 | Machine Gun G36 | Machine Gun | Yes | - |
| High Roller | Machine Gun | Raid Mode only (Legendary weapon) | - |
 | Rifle M40A1 | Rifle | Yes | - |
 | Rifle PSG1 | Rifle | Yes; campaign reward for the mission Secret Sign 15 | - |
| Muramasa | Rifle | Raid Mode only (Legendary weapon) | - |
 | Rocket Launcher | Rocket Launcher | Yes | A powerful rocket launcher. The fire once and throw away type. |
| Infinite Rocket Launcher | Rocket Launcher | Yes; campaign reward for the mission HELL Cleared | Fires powerful rockets and never needs to be reloaded. |
 | Knife | Knife | Yes | A multi-purpose knife with titanium coating. |
 | Pulse Grenade | Grenade | Yes | Delivers a powerful high frequency pulse, causing temporary paralysis. |
 | Shock Grenade | Grenade | Yes | A hand grenade that releases a high-voltage electric shock. |
A dash means the weapon has no description.